Activating p53 by mouse double minute 2 (MDM2) inhibitors, a class of p53-activating agents, could upregulate MHC class II in p53-WT but not p53-knockdown (KD) acute myeloid leukemia (AML) cells, suggesting that the regulation of MHC II by MDM2 inhibitor is p53 dependent [49]. This evidence concerns the gene TP53 and acute myeloid leukemia.