Furthermore, in the control group, BC patients without exercise training, levels of SOD1 promoter methylation increased at the end of experimental protocol (Control group PRE vs. POST, 0.042 ± 0.012 vs. 0.079 ± 0.022% 5mC, p < 0.0001) and when compared with the same experimental point in the exercise group (POST: CG vs. EG, 0.079 ± 0.022 vs. 0.034 ± 0.011% 5mC, p < 0.0001), whereas physical activity was able to prevent this increase as SOD1 promoter methylation levels were maintained in the exercise training group. Here, SOD1 is linked to breast cancer.