Specifically, PA was effective in reducing the promoter methylation of SOD2 (Exercise group PRE vs. POST, 18.915 ± 3.947 vs. 15.188 ± 3.424% 5mC, p = 0.002), and L3MBTL1 (Exercise group PRE vs. POST, 53.613 ± 8.057 vs. 39.946 ± 6.987% 5mC, p = 0.0005) in the BC training group. Here, SOD2 is linked to breast cancer.