Rearrangements involving KMT2A have been shown to occur in precursors in B-acute lymphoblastic leukemia (B-ALL), T-acute lymphoblastic leukemia (T-ALL), acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), mixed-lineage (biphenotypic) leukemia (MPAL), and secondary leukemia [51]. Here, KMT2A is linked to myelodysplastic syndrome.