CD4 and central nervous system cancer: These bone marrow-derived CCR2+/CX3CR1+ cells also co-express markers that correspond to M-MDSCs, namely, CD45+, CD11b+, Ly6Chi, and Ly6G−, migrate to glioma-secreted CCL2 and CCL7, and suppress the proliferation and IFN-γ secretion of both CD4+ and CD8+ T cells [17,18].