CD274 and neoplasm: For example, the Epstein–Barr virus (EBV) latent membrane protein 1 (LMP1), a critical viral oncoprotein, can foster an immunosuppressive tumor microenvironment (TME) by upregulating PD-L1 and immunosuppressive cytokines in EBV-related classical Hodgkin lymphomas (cHLs) [13].