Perhaps the most heavily studied in HNSCC is bintrafusp alfa (BA), which consists of an IgG1 anti-PD-L1 component fused to the extracellular domain of TGF-BRII, shown to effectively bind all three isoforms of TGF-β (Figure 4) [92]. This evidence concerns the gene TGFB1 and head and neck squamous cell carcinoma.