With reduction in TSGA10 level, the rates of CAFs in TME is elevated, which provides several benefits for cancer cells promotion by providing substrates for OxPhos of cancer cells (including pyruvate, lactate, and glutamate) [67], transferring mitochondria to cancer cells via nanotubes to support their metabolism [68], inducing tumor-promoting autophagy by releasing β-HB, IGF1/2, and CXCL12 [69], and inhibiting anti-tumor immune response [70]. The gene discussed is IGF1; the disease is cancer.