CXCL12 and breast cancer: Jahani et al. (2020) found that TSGA10 overexpression in breast cancer cells could reduce the expression of HIF-1 target genes, including MMP7 (matrix metalloproteinase-7), GLUT1 (glucose transporter 1), CXCR4 (C-X-C chemokine receptor type 4), CXCL12 (C-X-C motif chemokine 12), LOXL2 (lysyl oxidase-like 2), and vimentin [14].