Within tumor cells, F. nucleatum induces pro-inflammatory signaling through the TNFα, NF-kB, and IL-6/IL-8 pathways [194,195,196] and promotes tumor growth, EMT, metastasis, and therapy resistance, while also suppressing NK cell-mediated tumor cell killing and T cell infiltration into tumors [29,98]. This evidence concerns the gene NFKB1 and neoplasm.