To determine the mechanism of ASCT2 regulating lipid metabolism in basal-like breast cancer, the UCSC database (http://genome.ucsc.edu/, accessed on 3 February 2023) was utilized to determine the promoter sequence of enzymes (ACLY, HMGCR, CPT1B), and then the putative TFs binding to them were predicted by PROMO and JASPAR. The gene discussed is HMGCR; the disease is breast carcinoma.