IDH-wt GBM is mainly diagnosed in adults aged 50 to 60, and patients have a median survival of 15 months [2,3], whereas IDH-mutant grade IV astrocytoma is mostly diagnosed between the ages of 35 and 45 and is the result of dedifferentiation from a low-grade astrocytoma [2,4]. The gene discussed is IDH1; the disease is astrocytoma (excluding glioblastoma).