Luminex bead-based assays were developed and used on a discovery cohort of 497 individuals (63 EGC, 113 advanced GC, 117 atypical hyperplasia (AH), and 204 H controls) to measure serum CEA and CA72-4 levels in combination with serum IL-6, IL-8, and TNFα levels, leading to the proposal of a diagnostic model [51]. The gene discussed is IL6; the disease is gastric cancer.