All of the aAbs were present at higher levels in patients with PL, EGC, and AGC than in H. Anti-RAE1 best discriminated GC patients at different stages, with AUCs of 0.710 (95% CI = 0.628–0.793), 0.745 (95% CI = 0.678–0.811), and 0.804 (95% CI = 0.750–0.858) for PL, EGC, and advanced GC, respectively. The gene discussed is RAE1; the disease is gastric cancer.