CHEK1 and non-small cell lung carcinoma: Similarly, another study conducted in non-small cell lung cancer cells showed that a Chk1/Chk2 inhibitor (AZD7762) radiosensitised the cells to X-ray irradiation as well as to carbon ions (50 keV/μm) to a similar degree in one cell line (A549), although the response to carbon ions was exacerbated in another (H1299) [138].