However, in contrast, a study performed in 3D pancreatic cancer models (Colo357 and MiaPaCa-2) found an enhanced radiosensitising effect following X-rays (DER values of 1.5–1.6), compared to low-LET proton irradiation (DER values of 1.3) following Chk1 inhibition via LY2606368 [136]. The gene discussed is CHEK1; the disease is familial pancreatic carcinoma.