BRCA2 and pancreatic neoplasm: Moreover, another study in pancreatic cancer models demonstrated an increase in radiosensitivity and a reduction in RAD51 foci formation following MK-8776 treatment with X-ray radiation and gemcitabine in MiaPaCa-2, BxPC-3 and AsPC-1 cell lines, however, this effect was not evident in BRCA-2-deficient Capan-1 cell lines [106].