The direct influence of Chk1 inhibition via AZD7762 on RAD51 activity was investigated in MiaPaCa-2 pancreatic cancer cells, where it was observed that RAD51 foci formation were prevented at 26 and 30 h post-irradiation, whereas there was an increase in γH2AX foci 24 h following the combination treatment [102]. This evidence concerns the gene CHEK1 and familial pancreatic carcinoma.