Furthermore, multiple studies have shown significant radiosensitisation of tumours in vivo, both in xenograft and patient-derived xenograft (PDX) mouse models, utilising various Chk1 inhibitors (AZD7762, MK-8776, CCT244747, LY2606368, SAR-020106) [95,100,102,103,104,105]. Here, CHEK1 is linked to neoplasm.