Additionally, a reduction in γH2AX foci resolution was observed following the combination of MK-1775 plus radiation compared to radiation alone in MiaPaCa-2 and MPanc-1 pancreatic cancer cells, but not in Capan-1 (BRCA-2-deficient) or HR-modified DLD-1 cells, which corresponded with the observed radiosensitivity [118]. Here, BRCA2 is linked to familial pancreatic carcinoma.