Furthermore, successful engraftments of DLBCL cell lines and primary cells were reported in the humanized strains, MISTRG and MISTRG6, that demonstrated the importance of human IL6 in the in vivo engraftment of a subset of DLBCL and the spleen infiltrations of U2932 cells occurred only at MISTRG engrafted with cord blood human hematopoietic stem cells or MISTRG6 [14,16]. This evidence concerns the gene IL6 and diffuse large B-cell lymphoma.