These authors showed on HNSCC tissue microarray from humans (corroborated by in vitro results on UM-SCC-1 (Millipore Sigma #SCC070), -22A (Millipore Sigma #SCC076), and -22B (Millipore Sigma #SCC077) cell lines that Bmi-1 function is inhibited and that CDDP-induced CSC self-renewal and tumor growth are suppressed by therapeutic inhibition of IL-6R. This evidence concerns the gene BMI1 and neoplasm.