PDGFRA and gastrointestinal stromal tumor: PDGFs, along with their corresponding receptors (PDGFRα and PDGFRβ), are expressed in diverse malignant tumor cells and tissues, including but not limited to NSCLC, gastrointestinal stromal tumor (GIST), pancreatic cancer, breast cancer, ovarian carcinoma, hepatocellular carcinoma (HCC), and neuroendocrine tumors [265,266,267].