ATG5 and non-small cell lung carcinoma: Inhibition of autophagy through ATG5 knockdown, shRNA-mediated downregulation of Beclin 1, or using CQ, 3-MA, and BAF A1 all led to decreased cytotoxicity of the combined treatment [101], whereas sertraline enhanced erlotinib-induced autophagy and improved the therapeutic efficacy of erlotinib in NSCLC cells.