USP13 and gastrointestinal stromal tumor: Subsequently, Gao et al. further demonstrated that a USP13 inhibitor causes ATG5 degradation and that the combination of the USP13 inhibitor with 3-MA enhances the efficacy of imatinib in a mouse xenograft model derived from GIST cells, which also indicates that imatinib resistance is associated with a cytoprotective role of autophagy [209].