In studies that restricted their analysis to established RCC predisposition genes (BAP1, EPCAM, FH, FLCN, MET, MITF, MLH1, MSH2, MSH6, PMS2, PTEN, SDHA, SDHB, SDHC, SDHD, TP53, TSC1, TSC2, and VHL), PLP variants were identified in 1–6% of individuals tested [4,5,6,8,11,12]. This evidence concerns the gene FH and renal cell carcinoma.