Using bioinformatic tools, we built a functional biological network using the 692 proteins whose representation in exosomes was statistically significant between the two groups, defining a cluster of proteins with specific functions related to cell detachment from the primary tumor (Rac1-enriched exosomes) or those that dictate liver specificity (ITGαV and ITGβ5-enriched exosomes). The gene discussed is ITGB5; the disease is neoplasm.