In agreement with previous reports on pancreatic cancer exosomes [23,78], we observed that UM-derived exosomes triggered the transactivation of HHSCs, which produced α-SMA and increased amounts of extracellular matrix (ECM) proteins such as FN1, FN-EDA, and Col1A1 as compared with controls. This evidence concerns the gene PROS1 and pancreatic neoplasm.