si-m/hVDAC1-B markedly decreased VDAC1 expression levels in the A549 and H446 cell lines by 90–95% (50 nM or 75 nM), and in the mouse lung cancer 2LL cell line by 60% (50 nM or 75 nM) (Figure 1B–E). The gene discussed is VDAC1; the disease is lung cancer.