Here, we demonstrated that, in a urethane-induced lung cancer mouse model, the Retro-Tf-D-LP4 peptide reached the lung and attenuated tumor growth (Figure 9B), and also decreased the expression of metabolic-related enzymes such as VDAC1 and the TCA cycle enzyme citrate synthase (Figure 9C–E). Here, VDAC1 is linked to neoplasm.