VDAC1 and cancer: We have demonstrated that both siRNA against VDAC1 and VDAC1-based peptides are effective in inhibiting tumor growth in several cancer models, were the si-hVDAC1 encapsulated in PLGA-PEI nanoparticles, crossed the blood–brain barrier (BBB) and reached tumors in the brain [17,18,19,25,26,47].