Here, we used urethane-induced lung cancer in a mouse model, representing high similarity with human lung carcinogenesis [52], to demonstrate that siRNA recognizing both human and murine VDAC1, si-m/hVDAC1-B, when encapsulated into PLGA-PEI nanoparticles and given intravenously, reached the lung-silenced VDAC1 expression and led to inhibition of tumor growth (Figure 2 and Figure 3). Here, VDAC1 is linked to lung carcinoma.