To explore the origin of the high heterogeneity, we further classified the samples into several subgroups due to their histologic types, which contain thymic squamous cell carcinoma (TSCC), adenocarcinoma, basaloid carcinoma, neuroendocrine carcinoma, etc. In particular, five studies provided sufficient information on TC subtypes, allowing for further analysis, and the meta-analysis of the TP53 mutation rate was performed on TSCCs. The gene discussed is TP53; the disease is thymus squamous cell carcinoma.