TXNIP and neoplasm: Furthermore, the tumor tissues of AOM/DSS-treated VDUP1 KO mice showed a significantly decreased number of TUNEL-positive cells compared to those of WT mice (Figure 4B), with an apoptotic index of 6.4 in VDUP1 KO mice versus 1.7 in WT mice (p < 0.0001; Figure 4D).