The tumor tissues of AOM/DSS-treated VDUP1 KO mice exhibited a significantly increased number of Ki-67-positive cells compared to those of WT mice (Figure 4A), with a Ki-67 index of 52.1 in VDUP1 KO mice versus 33.4 in WT mice (p < 0.0001; Figure 4C). This evidence concerns the gene TXNIP and infectious otitis media.