VDUP1 KO mice showed significantly increased tumor number (Figure 3C) and size (Figure 3D) after AOM/DSS treatment compared to WT mice, with a mean tumor number of 7.1 in VDUP1 KO mice versus 2.8 in WT mice (p < 0.0001; Figure 3C) and mean of tumor size of 10.6 mm2 in VDUP1 KO mice versus 6.8 mm2 in WT mice (p < 0.001; Figure 3D). Here, TXNIP is linked to neoplasm.