At this depth, the clinically relevant gene fusions in all five previously determined fusion-positive AML cases were detected (two RUNX1::RUNX1T1 fusions, one CBFB::MYH11 fusion, one CBFA2T3::GLIS2 fusion, and one KMT2A::MLLT4 fusion) (Table 1). The gene discussed is RUNX1; the disease is acute myeloid leukemia.