In smouldering (MM) and MM, the definition of a poor outcome (i.e., associated with a high-risk profile) is mainly related to punctual PCs’ cytogenetic characteristics and the out-of-range values of biochemical parameters, such as serum β2-microglobulin (β2M) and lactate dehydrogenase (LDH) [2]. The gene discussed is HLA-G; the disease is Miyoshi myopathy.