In a recent report by Yang et al., the authors concluded that through stimulation of exosomal circRNA CDR1as secreted by mast cells, IgE influences endothelial dysfunction by dysregulating adhesion molecules intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) [124,125]. Here, ICAM1 is linked to endothelial dysfunction.