In a recent report by Yang et al., the authors concluded that through stimulation of exosomal circRNA CDR1as secreted by mast cells, IgE influences endothelial dysfunction by dysregulating adhesion molecules intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) [124,125]. This evidence concerns the gene VCAM1 and endothelial dysfunction.