It also explores the association between VHL loss and the activation of the mTOR pathway [119], highlighting the significance of various pVHL substrates, such as ZNF395, ZHX2, SFMBT1, RSUME, and TBK1, in the pathogenesis of clear cell renal cell carcinomas [136,137,138]. Here, SFMBT1 is linked to clear cell renal carcinoma.