In 2016, the World Health Organization (WHO) revised the diagnostic criteria for PV, which includes three major criteria, namely elevated Hb [>16.5 g/dL(men), >16.0 g/dL (women)] or hematocrit (Hct) [>49% (men), >48% (women)] specific for sex, hypercellularity with panmyelosis of the bone marrow, the presence of the JAK2 V617F or JAK2 exon 12 mutation, and one minor criterion of subnormal sEPO [11]. This evidence concerns the gene JAK2 and acquired polycythemia vera.