CX3CL1 and peripheral arterial disease: Cytokine-induced neutrophil chemoattractant 1 (CINC-1) [4], a cluster of differentiation 95 (CD95) [5], fractalkine [6], and T-cell immunoglobulin and mucin domain 1 (TIM-1) [7] are circulating proteins that have been extensively studied in relation to cardiovascular diseases such as coronary artery disease (CAD), cerebrovascular disease (CVD), and PAD.