Finally, after examining the expression of target proteins after the stimulation of melanoma cells by α-melanocyte-stimulating hormone, it was concluded that the aqueous and ethanolic extracts altered the expression of genes involved in melanogenesis and cell proliferation (ERK, P-ERK, AKT, P-AKT), as well as enabling the inhibition of tyrosinase gene expression. Here, TYR is linked to melanoma.