In this study, a high dose of the GABA-rich adzuki bean reduced the hepatic state of T2DM mice induced by HFD + STZ, promoted glycogen synthesis in the liver of T2DM mice, inhibited the activities of gluconeogenesis rate-limiting enzymes PEPCK and G-6-Pase in liver tissue, and significantly down-regulated the gene expression levels of PEPCK, G6PC and FOXO1, which are downstream factors of the insulin pathway. This evidence concerns the gene FOXO1 and type 2 diabetes mellitus.