At the same time, TF3 and TS can significantly alleviate the phenomenon of high GSK3β protein levels caused by hyperglycemia and significantly down-regulate the expression level of the GSK3β protein in T2DM mice livers, but the expression level of GSK3β total protein in the TF3 group is still at a higher level than that in the C and TS groups. The gene discussed is GSK3B; the disease is type 2 diabetes mellitus.