On the one hand, TF3 intervention can significantly increase the activity of IRS-1, which is the insulin receptor substrate in the liver tissue of T2DM mice, and then increase the level of AKT protein and AKT protein phosphorylation through a PI3K series cascade reaction, enhance insulin conduction ability, and relieve IR symptoms by improving insulin sensitivity. The gene discussed is INSR; the disease is type 2 diabetes mellitus.