NFE2L2 and cancer: Along with capsaicin, other compounds present in pepper extracts, such as vitamins C and E, provitamin A, carotenoids, and phenolic compounds, can also reduce cardiovascular and cancer-related complications, attenuating the cellular oxidative status by scavenging reactive oxygen and nitrogen reactive species and reducing inflammation through the nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor-kappaB (NFκB) signaling pathways [13,14,15,16,17].