SERPINE1 and diabetes mellitus: Amar et al. [86] in their study of the effects of probiotics on bacterial translocation and glucose metabolism in high-fat diet-induced diabetic mice, found that Bifidobacterium animalis Lactobacillus 420 application was able to alter the bacterial translocation in the early stages of diabetes and reduce cytokines in tissues TNF-α, IL-1β, plasminogen activator inhibitor-1 (PAI-1), and IL-6 expression.