Lactobacillus plantarum JY039 extracellular polysaccharide and Lactobacillus paracasei JY062 alleviated T2DM by balancing pro-inflammatory factor IL-6, TNF-α, and anti-inflammatory factor Interleukin-10 (IL-10) to reduce inflammation [87]. The gene discussed is TNF; the disease is type 2 diabetes mellitus.