Resveratrol has been shown to indirectly suppress HK II by reducing the translocation of HK II to the outer mitochondrial membrane (OMM) via the inhibition of the receptor tyrosine kinase (RTK)/phosphoinositide-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway in a range of cancer cell types [98]. Here, HK2 is linked to cancer.