KEGG enrichment analysis revealed that the 23 intersecting targets were enriched in 90 signaling pathways (p < 0.05, Supplementary Table S5), including the vascular smooth muscle contraction (hsa04270), aldosterone-regulated sodium reabsorption (hsa04960), renal cell carcinoma (hsa05211), and TNF signaling pathway (hsa04668), among others (Figure 4A). The gene discussed is TNF; the disease is hereditary clear cell renal cell carcinoma.