In the comparisons of S_M, H_M, and H_S, the GO enrichment analysis showed that the upregulated genes in BPs were mainly enriched in negative chemotaxis, the extrinsic apoptotic signaling pathway in the absence of ligand, small GTPase-mediated signal transduction, and regulation of ERK1 and ERK2 cascade. The gene discussed is MAPK3; the disease is Bartsocas-Papas syndrome 1.