The tumor reduction also translated into better survival with M1 + NextA followed by NextA and M1 groups, as shown by the Kaplan-Meier survival plot in Fig. 4C. More importantly, we also observed that ACT with BMDMs derived from HDAC6 knockout mouse recapitulated the results of M1 + NextA (Fig. 4D). The gene discussed is HDAC6; the disease is neoplasm.