Another preclinical model, the patient derived xenograft (PDX) mouse model for AITL is not mimicking closely the T cell lymphoma since upon transplantation of human AITL biopsies into NSG mice the CD8 T cells and B cells do not engraft anymore and only the CD4 + PD1highneoplastic cells persist. Here, CD4 is linked to angioimmunoblastic T-cell lymphoma.