In leukemic T lymphoblasts, cytokines and chemokines including INFγ, IL-16 and C-C motif chemokine ligand 6 (CCL6) were released, which are the chemoattractants inducing the movement of tumor-associated macrophages (TAMs) toward the tumor-infiltrated tissues, and these molecules largely rely on the expression and function of STIM1 and STIM2 in the infiltrated tumor cells. The gene discussed is IL16; the disease is neoplasm.