In CRC, STIM2 loss leads to the increase of SERCA2-dependent ER Ca2+, and then activates c-Myc and the PERK/ATF4 branch of ER stress facilitating the increased protein translation and transcriptional and metabolic rewiring which support increased tumor size, invasion, and metastasis [56]. The gene discussed is STIM2; the disease is colorectal carcinoma.