Various pathogenic genes associated with HAE have been reported, including Serine Protease Inhibitor G1 (SERPING1), Factor XII (F12), Plasminogen (PLG), myoferlin gene mutation (MYOF), kininogen-1 (KNG1), heparan sulfate-glucosamine 3-O-sulfotransferase 6 (HS3ST6), and Angiopoietin 1 (ANGPT 1) [3]. The gene discussed is SERPING1; the disease is hereditary angioedema.