Bubbles 1, 2, and 3 were associated with high expression of SLPI, S100A9, and PIP4K2C, respectively, and based on data from the Cancer Dependency Map Portal (https://depmap.org; accessed 23.06.2022) we were able to confirm that these genes are typically over-expressed in cell lines H838, H2228, and HCC827, respectively. The gene discussed is S100A9; the disease is cancer.