The pretreatment of A549 cells with MnTMPyP was sufficient to rescue DNA damage upon concurrent ERK5 and CDK5 or FAK inhibition (Figs. 4F and  EV4B) Moreover, MnTMPyP treatment resulted in a complete recovery of the proliferative capacity of cancer cells treated with a combination of ERK5 and CDK5 or direct FAK inhibition (Fig. 4G). This evidence concerns the gene PTK2 and cancer.