IRF3 and ovarian carcinoma: Importantly, results derived from analyzing human patient data extracted from GTEx and TCGA datasets demonstrated that expression of genes encoding key components of the innate immune signaling pathways, such as DHX58, IRF3, STAT5A, STAT6, and JAK1, are significantly downregulated in ovarian cancer tissues when compared to normal control (Fig. EV4), verifying the clinical relevance of our observations.