Our observation that HPV drives massive pelvic metastasis (peritoneum mesothelium, omentum, diaphragm, and pancreas) of YAP1-induced fallopian tube HGSC provides a clue for our understanding of the metastasis of human HGSOC, and opens a window for developing new strategies to effectively prevent tumor metastasis by eradicating HPV infection and thereby improve the patient survival rate. The gene discussed is YAP1; the disease is neoplasm.