TP53 and neoplasm: Previous mechanistic studies demonstrated that high-risk HPV E6 and E7 proteins target TP53 and RB1 tumor suppressors and human TERT to increase cell viability, promote cell proliferation, and drive tumorigenesis in tissues that are frequently exposed to HPV, such as the cervix and skin (Gewin and Galloway, 2001; Jones et al, 1997; Reznikoff et al, 1994; Veldman et al, 2001; Werness et al, 1990).