Our recent studies indicated that human papillomavirus (HPV) oncoprotein E6 stabilizes the YAP1 protein in cervical epithelial cells to drive the development of cervical cancer (He et al, 2015b), suggesting that pathogenic microorganisms may interact with YAP1 to drive the carcinogenesis of epithelial layer in the female reproductive tract. The gene discussed is YAP1; the disease is cervical carcinoma.