CXCR1 and central nervous system cancer: CXCL8 (also known as interleukin 8, IL-8) is an inflammatory chemokine that can interact with CXCR1 and CXCR2.83 Ringe et al. found that MSCs migrate to zones with high concentrations of CXCL8 in a dose-dependent manner through in vitro chemotaxis assays.83 This process was observed in gliomas, in which CXCL8 was identified as an inducer of human umbilical cord blood-derived MSC migration toward glioma cells both in vitro and in vivo.84,85