IL6R and type 1 diabetes mellitus: Most of the mutations had an allele frequency of <0.01 with the notable exceptions of rs2228145 (minor allele frequency [MAF] =0.39) in IL6R as well as rs12720356 (MAF=0.09) and rs2304256 (MAF=0.28) in TYK2. Summary statistics for both drug target level and type 1 diabetes risk were available for nine variants.