Intrinsic or constitutive PD-L1 overexpression is associated with the presence of multiple molecular mechanisms such as genetic amplification of chromosome 9, which contains the locus of PD-L1 and PD-L2, MYC overexpression, and EGFR or ALK alterations observed in NSCLC [57]. The gene discussed is CD274; the disease is non-small cell lung carcinoma.