In several cancers such as colon cancer, mutations in the destruction complex components (APC, AXIN2, and FAM123B/WTX) or regulators of the receptors/ligand (RNF43/ZNRF3, RSPO2, or RSPO3) components can lead to unchecked Wnt signaling [49]. The gene discussed is AMER1; the disease is malignant colon neoplasm.