We found that endogenous E-cadherin was co-immunoprecipitated with USP11 (Fig. 3A), and reciprocally, endogenous USP11 was also co-immunoprecipitated with E-cadherin (Fig. 3B), indicating that USP11 and E-cadherin bind to each other in human breast cancer cells. The gene discussed is CDH1; the disease is breast carcinoma.