Our present study confirms this theory and describes, for the first time, huntingtin inclusions in the caudate nucleus and frontal cortex of three MND individuals carrying HTT RP and IA gene expansions (Fig. 2b-d, Fig. 3f and Fig. 4b,c), in addition to classical ALS-related pathology (Fig. 2e-f, Fig. 3a-e and Fig. 4a + d-f). The gene discussed is HTT; the disease is amyotrophic lateral sclerosis.