Additionally, in HrasG12V‐mutated hepatocellular carcinoma (HCC), senescent HCC cells secrete SASP factors (such as CCL2, IL‐15 and CXCL1) that activate macrophages, neutrophils and NK cells, thereby mediating innate immunity and suppressing tumour progression.16 This evidence concerns the gene CXCL1 and neoplasm.