Conversely, in another study, Jak2/Stat3 inactivation within Pten‐null senescent tumours alters the immunosuppressive properties of SASP by decreasing the levels of specific cytokines (such as CXCL2, GM‐CSF, M‐CSF, C5a, IL‐10, IL‐13) in the TME, thereby facilitating the transition from immunosuppression to active immune surveillance.18 This evidence concerns the gene CXCL2 and neoplasm.