ORAI1 and immunodeficiency disease: Whether ITPR3-based immunodeficiency disease belongs within CRAC channelopathies is at this point more a matter of semantics than medicine (although we believe that the observed phenotype is larger than those identified in CRAC channelopathies), yet it is of interest to briefly compare the phenotype of patients reported here with those suffering from ORAI1 and STIM1 null or LoF variants.