Here is a summary: ITPR1 KO die in utero or soon after birth while displaying ataxia and severe seizures (39), a neurological phenotype not dissimilar with those seen in man (see above and OMIM #147265); ITPR2 KO live an extended life span (40), along with reported cardiac rhythmogenesis abnormalities (41) but perhaps more remarkably with sweat gland abnormalities matching perfectly anhidrosis found in man (see above and OMIM #600144); whereas ITPR3 KO mice were reported to have abnormal taste perception (42) or yet alopecia (43), none matching findings in man (see above and OMIM #147267). Here, ITPR2 is linked to cerebellar ataxia.