In previous GWAS and clinical studies, these genes have been associated with neurogenesis (WNT3) [89,90], neurodevelopmental delays (QRICH1) [91,92], addiction (HCG27) [93], depression (CCDC71, CYP21A2) [94,95], and other brain-related disorders [96,97]. This evidence concerns the gene CYP21A2 and major depressive disorder.