PPARGC1A and cancer: Inhibition of Esrra has also been shown in cancer cell metabolism studies to interfere with pyruvate entry in mitochondria by inhibiting the expression of Mpc1 (Park et al., 2019), and inhibition of Esrra led to decreased expression of Ppargc1a-controlled expression of mitochondrial genes in mice brains (Bronte and Pittet, 2013).