To investigate the potential role of Vangl2 in inflammatory response, we first analyzed the expression of Vangl2 in peripheral blood mononuclear cells (PBMCs) from sepsis patients (Figure 1—figure supplement 1A) and found mRNA level of Vangl2 was increased in the sepsis patients compared to healthy control (Figure 1A). The gene discussed is VANGL2; the disease is Sepsis.